adiponectin gene polymorphisms and susceptibility to atherosclerosis: a meta‑analysis

normal 0 false false false en-us x-none ar-sa previous studies have inspected the associations between adiponectin (adipoq) 276g/t polymorphisms and atherosclerosis, but the results are inconclusive. the aim of this study was to explore the relationship between polymorphism +276 g > t (rs1501299) in adipoq and atherosclerosis. a widespread search was directed to identify all studies on the association of adipoq 276g/t polymorphism with atherosclerosis risk. the fixed effect pooled measures according to odds ratio (or) and 95% confidence interval (ci) were calculated in the meta-analysis. heterogeneity among studies was evaluated using q test and the i 2 . publication bias was estimated using modified egger’s linear regression test and fuunel plot. nine studies regarding the associations between the adipoq 276g/t polymorphism and atherosclerosis risk were enrolled in this meta-analysis, including 1959 cases and 3739 controls. the 276g/t polymorphism was not significantly associated with atherosclerosis, yielding pooled ors of 0.925 (95% ci: 0.728-1.178) and 0.921 (95% ci: 0.804-1.054), for tt versus gg, and tg versus gg, respectively. significant between-study heterogeneity was not found in our meta-analysis. furthermore there was no evidence of publication bias in the meta-analysis. the present meta-analysis showed that there is no association between adipoq 276g/t polymorphism and atherosclerosis. high quality studies are still needed to add for more investigation of the association between adipoq 276g/t polymorphisms and atherosclerosis.